李松涛 教授
医学博士，中西医结合基础博士生导师。现任美高梅MGM官网健康风险暴露与慢病研究所所长、美高梅mgm1888营养与健康研究所所长，担任中国营养学会基础营养学分会常务委员等学术兼职。主要从事酒精性肝病的病理机制及防治研究，主持国家自然基金项目等科研项目20余项。作为主要完成人获得科研奖励7项。以通讯或第一作者在Hepatology、Journal of Hepatology、American Journal of Clinical Nutrition等刊物发表SCI论文40余篇；获得授权发明专利9件，其中国际专利1件。副主编“十四五”规划教材《医学营养学》、《健康营养学》，参编“十四五”规划教材《预防医学》、“十三五”规划教材《中医饮食养生学》等。
研究方向：酒精性肝病的病理机制及防治研究
联系方式：
地址：杭州市滨江区滨文路548号
电话：0571-86633048
邮箱：lisongtao@zcmu.edu.cn
主要承担项目：
1. 国家自然科学基金面上项目，82273625，CYP2B6在酒精性脂肪肝病中的生物学作用及烟酰胺单核苷酸干预研究，2023/01-2026/12，52万，主持
2. 浙江省自然科学基金-杰出青年基金，LR20H260001，TRPC3在非酒精性脂肪性肝炎病理过程中的作用 及机制研究，2020/01-2023/12，主持
3. 国家自然科学基金面上项目，81973041，瞬时受体电位通道3在高脂膳食诱导的非酒精性脂肪性肝炎中的作用及机制研究，2020/01-2023/12，54万，主持
4. 国家自然科学基金面上项目，81773422，雌激素缺乏状态下补钙对动脉粥样硬化斑块形成的影响及机制研究，2018/01-2021/12，主持
5. 国家自然科学基金面上项目，81573132，自噬对高脂膳食诱导的血管内皮细胞损伤的保护作用及分子机制研究，2016/01-2017/12，主持
代表性论文：
1. Qinchao Ding #, Rui Guo#, Liuyi Hao #, Qing Song, Ai Fu, Shanglei Lai, Yanli Chen, Tiantian Xu, Haibin Wei, Daxi Ren, Zhaoli Sun, Zhenyuan Song, Xiaobing Dou*, Songtao Li*. Hepatic TRPC3 loss contributes to chronic alcohol consumption-induced hepatic steatosis and liver injury in mice. Life Metabolism. 2024. 3(1): load050.
2. Jiannan Qiu, Fan Dong, Hui Zhuge, Qiang Han, Jiaomei Li, Rui Guo, Xiaobing Dou, Jiayu Li, Songtao Li*. Preventive effect of low-carbohydrate high-fat dietary pattern on liver disease caused by alcohol consumption via a 6pgd-involved mechanism in mice. Food & Function. 2024. 15(2): 732-746
3. Linwensi Zhu#, Na Ying #, Liuyi Hao, Ai Fu, Qinchao Ding, Feiwei Cao, Daxi Ren, Qiang Han*, Songtao Li*. Probiotic yogurt regulates gut microbiota homeostasis and alleviates hepatic steatosis and liver injury-induced by high-fat diet in golden hamster. Food Science & Nutrition. 2024.
4. Shanglei Lai#, Yue Ma#, Liuyi Hao#, Qinchao Ding, Kaixin Chang, Gehui Zhu, Jiannan Qiu, Tiantian Xu, Xiaobing Dou*, Songtao Li*. 1-Methylnicotinamide promotes hepatic steatosis in mice: a potential mechanism in chronic alcohol-induced fatty liver disease. BBA-Molecular and Cell Biology of Lipids. 2023. 1868(4): 159286.
5. Haibin Wei#, Yujie Yin#, Wenwen Yang, Jinyan Zhu, Lin Chen, Rui Guo, Zhen Yang, Songtao Li*. Nuciferine Induces Autophagy to Relieve Vascular Cell Adhesion Molecule 1 (VCAM1) Activation via Repressing Akt/mTOR/AP1 signal pathway in Vascular Endothelium. Frontiers in Pharmacology. 2023. 14:1264324.
6. Rui Guo#, Lin Chen#, Jinyan Zhu, Jiaomei Li, Qinchao Ding, Kaixin Chang, Qiang Han, Songtao Li*. Monounsaturated fatty acid enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice. Food & Function. 2023, DOI: 10.1039/D2FO03323B
7. Feiwei Cao#, Qinchao Ding#, Hui Zhuge, Lai Shanglei, Kaixin Chang, Chunyan Le, Guorong Yang, Teresa G Valencak, Songtao Li*, Daxi Ren*. Lactobacillus plantarum ZJUIDS14 alleviates non-alcoholic fatty liver disease in mice in association with modulation in the gut microbiota. Frontiers in Nutrition. 2023, doi: 10.3389/fnut.2022.1071284
8. Yue Ma#, Qinchao Ding#, Qianyu Qian, Luyan Feng, Qin Zhu, Caijuan Si, Xiaobing Dou*, Songtao Li*. AMPK-regulated autophagy contributes to ursolic acid supplementation-alleviated hepatic steatosis and liver injury in chronic alcohol-fed mice. ACS Omega. 2023. DOI 10.1021/acsomega.2c06252
9. Rui Guo#, Jinyan Zhu#, Lin Chen#, Jiaomei Li, Qinchao Ding, Qiang Han, Weijun Zheng, Songtao Li*. Dietary Camellia Seed Oil Attenuates Liver Injury in Mice Chronically Exposed to Alcohol. Frontiers in Nutrition. 2022, 9: 1026740. doi: 10.3389/fnut.2022.1026740.
10. Fei Zhao#, Jun Chen#, Rui Guo, Jinyan Zhu, Weijia Gu, Songtao Li*, and Jiaomei Li*. Absolute quantitative lipidomics reveals lipids profiling in liver of mice with early-stage alcoholic liver disease. Nutrition & Metabolism. 2022, 19(1): 42. doi: 10.1186/s12986-022-00679-z
11. Wenwen Yang#, Rui Guo#, Aiwen Pi, Qinchao Ding, Liuyi Hao, Qing Song, Lin Chen, Xiaobing Dou, Lixin Na, Songtao Li*. Long chain non-coding RNA-EN_181 contributes to the protective role of N-acetylcysteine against non-alcoholic fatty liver disease in mice. British Journal of Nutrition. 2022, 17:1-15.
12. Ai Fu#, Jiaomei Li#, Qinchao Ding, Rui Guo, Aiwen Pi, Wenwen Yang, Yanli Chen, Xiaobing Dou, Zhenyuan Song, Songtao Li*. Upregulation of 4-hydroxynonenal contributes to the negative effect of n-6 polyunsaturated fatty acid on alcohol-induced liver injury and hepatic steatosis. Journal of Agricultural and Food Chemistry. 2022, 70(21): 6418-6428.
13. Qinchao Ding#; Feiwei Cao#; Shanglei Lai; Hui Zhuge; Kaixin Chang; Teresa G. Valencak; Jianxin Liu; Songtao Li*, Daxi Ren*. Lactobacillus plantarum ZY08 relieves chronic alcohol-induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis. Food Research International. 2022. 157: 111259.
14. Wenwen Yang#, Linwensi Zhu#, Shanglei Lai#, Qinchao Ding, Tiantian Xu, Rui Guo, Xiaobing Dou, Hui Chai, Zhiling Yu, Songtao Li*. Cimifugin ameliorates lipotoxicity-induced hepatocytes damage and steatosis through TLR4/p38 MAPK and SIRT1 involved pathways. Oxidative Medicine and Cellular Longevity. 2022, 20: 4557532, doi.org/10.1155/2021/4557532.
15. Qinchao Ding#, Rui Guo#, Liuhua Pei, Shanglei Lai, Jiaomei Li, Yujie Yin, Tiantian Xu, Wenwen Yang, Qing Song, Qiang Han, Xiaobing Dou, Songtao Li*. N-acetylcysteine alleviates high fat diet-induced hepatic steatosis and liver injury via regulating intestinal microecology in mice. Food & Function. 2022. 13(6): 3368-3380. doi.org/10.1039/D1FO03952K
16. Songtao Li*, Zhenyuan Song, Ping Yao, Jiangjiang Qin. Editorial: Alcohol Consumption and Liver Diseases: From Pathology to Phytotherapy. Frontiers in Pharmacology. 2022, 16: 848334. DOI: 10.3389/fphar.2022.848334
17. Zhongyan Du#, Zhimei Ma#, Lai Shanglei#, Qinchao Ding, Ziyi Hu, Wenwen Yang, Qianyu Qian, Linwensi Zhu*, Xiaobing Dou*, Songtao Li*. Atractylenolide I Ameliorates Acetaminophen-induced Acute Liver Injury via a TLR4/MAPKs/NFκB involved Signaling Pathway. Frontiers in Pharmacology. 2022, 16: 797499. DOI: 10.3389/fphar.2022.797499
18. Cui Wang#, Songtao Li#, Qingsheng Liu,Qianyu Qian,Ai Fu,Lin Chen,Lei Zhang,Toshinobu Suzaki, ZhiLing Yu, Xiaobing Dou*. Ectopic accumulation of ceramide in cardiomyocytes modulates alcoholic cardiomyopathy via the TLR4-dependent pathway. Alcoholism: Clinical and Experimental Research. 2022, 46(6): 1011-1022. doi.org/10.1111/acer.14822
19. Qinchao Ding#, Yue Ma#, Shanglei Lai, Xiaobing Dou*, Songtao Li*. NNMT aggravates hepatic steatosis, but alleviates liver injury in alcoholic liver disease. Journal of Hepatology, 2021, 74(5):1248-1250. doi.org/10.1016/j.jhep.2020.11.025
20. Aiwen Pi#, Kai Jiang#, Qinchao Ding, Shanglei Lai, Wenwen Yang, Jinyan Zhu, Rui Guo, Yibin Fan, Linfeng Chi*, Songtao Li* Alcohol abstinence rescues hepatic steatosis and liver injury via improving metabolic reprogramming in chronic alcohol-fed mice. Frontiers in Pharmacology. 2021, 12:752148. doi: 10.3389/fphar.2021.752148
21. Xiaobing Dou#, Wenwen Yang#, Qinchao Ding, Qiang Han, Qianyu Qian, Zhongyan Du, Yibin Fan, Cui Wang*, Songtao Li*. Comprehensive Analysis of the Expression Profiles of Hepatic lncRNAs in the Mouse Model of Alcoholic Liver Disease. Frontiers in Pharmacology. 2021, 12:709287. doi: 10.3389/fphar.2021.709287
22. Jianfei Lai#, Qianyu Qian#, Qinchao Ding, Li Zhou, Ai Fu, Zhongyan Du, Cui Wang, Zhenyuan Song, Songtao Li*, Xiaobing Dou*. Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High-Fat Diet Fed Male Mice. Frontiers in Pharmacology. 2021, 12: 614406. doi: 10.3389/fphar.2021.614406
23. Zhen Yang#, Yanli Chen#, Zhaoyuan Yan, Tiantian Xu, Xiangyao Wu, Aiwen Pi, Qingsheng Liu, Hui Chai, Songtao Li* and Xiaobing Dou*. Inhibition of TLR4/MAPKs pathway contributes to the protection of salvianolic acid A against lipotoxicity-induced myocardial damage in obese mice. Frontiers in Pharmacology, 2021, 12: 627123. doi: 10.3389/fphar.2021.627123
24. Tiantian Xu#, Qing Song#, Li Zhou, Wenwen Yang, Xiangyao Wu, Qianyu Qian, Hui Chai, Qiang Han, Hongzhi Pan, Xiaobing Dou *, Songtao Li *. Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes. Nutrition & Metabolism. 2021,18(1):13. doi.org/10.1186/s12986-021-00540-9
25. Li Zhou#, Hua Ning#, Haibin Wei, Tiantian Xu, Xindi Zhao, Ai Fu, Qianyu Qian, Zhen Yang, Xiaobing Dou*, Songtao Li*. A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone-(tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium. Oxidative Medicine and Cellular Longevity. 2020, 11：6584059
26. Songtao Li#, Qianyu Qian#, Na Ying, Jianfei Lai, Luyan Feng, Sitong Zheng, Fusheng Jiang, Qing Song, Hui Chai* and Xiaobing Dou*. Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice. Frontiers in Pharmacology. 2020. 11:560905
27. Xiaobing Dou#, Luyan, Feng#，Na Ying, Qinchao Ding, Qing Song, Fusheng Jiang F, Cui Wang*, Songtao Li*. RNA sequencing revealed a comprehensive circular RNA expression profile in a mouse model of alcoholic liver disease. Alcohol Clin Exp Res. 2020, 44(2):415-422. doi: 10.1111/acer.14265
28. Xiaobing Dou#, Qinchao Ding#, Shanglei Lai, Fusheng Jiang, Qing Song, Xindi Zhao, Ai Fu, Naima Moustaid-Moussa, Dongju Su*, Songtao Li *. Salidroside alleviates lipotoxicity-induced cell death through inhibition of TLR4/MAPKs pathway, and independently of AMPK and autophagy in AML-12 mouse hepatocytes. Journal of Functional Foods. 2020.02, 65：103691
29. Yue Ma#, Hui Chai#, Qinchao Ding, Qianyu Qian, Zhaoyuan Yan, Bin Ding, Xiaobing Dou*, Songtao Li*. Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice. Frontiers in Physiology. 2019, 10:1042. doi: 10.3389/fphys.2019.01042
30. Xiaobing Dou#, Songtao Li#, Linfeng Hu, Lei Ding, Yue Ma, Wang Ma, Hui Chai, Zhenyuan Song. Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease. Exp Mol Med. 2018; 50(4):7.
31. Songtao Li#, Xiaobing Dou#, Hua Ning, Ximei Zhang, Chen Shen, Jiaxin Li, Zhenyuan Song. Sirtuin 3 Acts As a Negative Regulator of Autophagy Dictating Hepatocyte Susceptibility to Lipotoxicity. Hepatology. 2017, 66(3):936-952.
32. Qing Song, Rui Guo, Wei Wei, Lin Lv, Zhenfeng Song, Renan Feng, Songtao Li*, Changhao Sun*. Histidine-alleviated Hepatocellular Death in Response to 4-hydroxynonenal Contributes to the Protection Against High-fat Diet-induced Liver Injury. Journal of Functional Foods. 2017.39:74-83
33. Songtao Li#, Hua Ning#, Yaxin Ye, Wei Wei,Rui Guo, Qing Song, Lei Liu,yuanyuan Liu,Lixin Na, Yuchun Niu, Xia Chu, Rennan Feng, Moustaid-Moussa Naima, Ying Li, Changhao Sun*. Increasing extracellular Ca2+ sensitizes TNF-alpha-induced vascular cell adhesion molecule-1 (VCAM-1) via a TRPC1/ERK1/2/NFκB-dependent pathway in human vascular endothelial cells. Biochimica et biophysica acta -molecular cell research. 2017;1864(10):1566-1577
