孙庆华 教授

中西医结合基础博士生导师，入选浙江省“千人计划”。1996年毕业于中国协和医科大学，获博士学位。曾在比利时布鲁塞尔自由大学（ULB）、美国哥伦比亚大学、密芝根大学、纽约大学、俄亥俄州立大学等院校学习和工作20余年，2021年入职美高梅MGM官网教授。主要从事大气细颗粒物对呼吸系统疾病、心血管系统疾病及衰老的影响及机制研究、气候变暖对人体健康和疾病发展的机制研究、行为方式改变和中药干预对健康的影响和疾病的预防。迄今为止，主持和承担包括NIH/NIEHS项目、HEI项目20余项，编写专著4部。在国内外学术期刊发表学术论文170余篇，包括JAMA、Circulation、Circulation Research、Particle & Fibre Toxicology、Am J Respir Crit Care Med、Arterioscler Thromb Vasc Biol等。曾获得Society of Critical Care Medicine (SCCM) “Clinical Pharmacy and Pharmacology Specialty Award”, Society of Toxicology (SOT) Inhalation & Respiratory Specialty Section “Paper of the Year Award”和“Young Investigator Award”，The Ohio State University“Distinguished Undergraduate Research Mentor Award”,和US Department of State“Fulbright Specialist grant award”等奖项。

研究方向：

大气污染对心肺及衰老的机制研究

气候变化对健康影响和疾病发展的机制研究及行为方式和中医药应对

联系方式：

地址：杭州市滨江区滨文路548号

电话：0571-86658105

邮箱：qhsun@zcmu.edu.cn

代表性论文：

1.Zhou J, Xu J, Geng F, Peng L, Ye X, Yang D, Zhao J,Sun Q. Childhood co-exposure of cold stress and PM2.5 aggravates the susceptibility and severity of asthma in adulthood of mice. Environ Toxicol. 2021;36:177-184.

2.Yang, S., Chen, R., Zhang, L., Sun, Q., Li, R., Gu, W., Zhong, M., Liu, Y., Chen, L.-C.,Sun, Q., Liu, C., Lipid metabolic adaption to long-term ambient PM2.5 exposure in mice. Environ Pollut. 2021;269:116193

3.Li L, Liu Y, Chiu C, Jin Y, Zhou W, Peng M, Chen LC,Sun Q, Gao J. A Regulatory Role of Chemokine Receptor CXCR3 in the Pathogenesis of Chronic Obstructive Pulmonary Disease and Emphysema. Inflammation. 2021;44:985-998.

4.Zhang G, Li R, Li W, Yang S, Sun Q, Yin H, Wang C, Hou B, Wang H, Yu L, Chen R, Shi L, Zhang K, Liew CW, Qiang G,Sun Q, Liu C. Toll-Like Receptor 3 Ablation Prevented High-fat Diet-induced Obesity and Metabolic Disorder. J Nutr Biochem. 2021 Sep;95:108761

5.Hu R, Zhang W, Li R, Qin L, Chen R, Zhang L, Gu W,Sun Q, Liu C. Ambient fine particulate matter exposure disrupts circadian rhythm and oscillation of the HPA axis in a mouse model. Ecotoxicol Environ Saf. 2021;222:112524.

6.Li R, Wang Y, Chen R, Gu W, Zhang L, Gu J, Wang Z, Liu Y,Sun Q, Zhang K, Liu C. Ambient fine particulate matter disrupts hepatic circadian oscillation and lipid metabolism in a mouse model. Environ Pollut. 2020;262:114179

7.Wang Y, Li R, Chen R, Gu W, Zhang L, Gu J, Wang Z, Liu Y,Sun Q, Zhang K, Liu C. Ambient fine particulate matter exposure perturbed circadian rhythm and oscillations of lipid metabolism in adipose tissues. Chemosphere. 2020;251:126392

8.Li R, Sun Q, Lam SM, Chen R, Zhu J, Gu W, Zhang L, Tian H, Zhang K, Chen LC,Sun Q, Shui G, Liu C. Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice. Part Fibre Toxicol. 2020;17(1):14

9.Li R, Wang Y, Hou B, Lam SM, Zhang W, Chen R, Shui G,Sun Q, Qiang G, Liu C. Lipidomics insight into chronic exposure to ambient air pollution in mice. Environ Pollut. 2020;262:114668.

10.Zhou J, Geng F, Xu J, Peng L, Ye X, Yang D, Zhao J,Sun Q. PM2.5 exposure and cold stress exacerbates asthma in mice by increasing histone acetylation in IL-4 gene promoter in CD4+ T cells. Toxicol Lett. Toxicology Letters. 2019;316:147–153

11.Sun Q, Zhang G, Chen R, Li R, Wang H, Jiang A, Li Z, Kong L, Fonken LK, Rajagopalan S,Sun Q, Liu C. Central IKK2 inhibition ameliorates air pollution mediated hepatic glucose and lipid metabolism dysfunction in mice with type II diabetes. Toxicol Sci. 2018;164:240-249.

12.Maciejczyk P, Jin L, Hwang J, Guo X, Zhong M, Thurston G, Qu Q, Zhang J,Sun Q, Chen LC. Association of Cardiovascular Responses in Mice with Source-apportioned PM2.5 Air Pollution in Beijing. Aerosol and Air Quality Research. 2018:18: 1839–1852

13.Chen H, Chen X, Hong X, Liu C, Huang H, Wang Q, Chen S, Chen H, Yang K,Sun Q. Maternal exposure to ambient PM2.5 exaggerates fetal cardiovascular maldevelopment induced by homocysteine in rats. Environ Toxicol. 2017;32:877-889

14.Liu CB, Hong XR, Shi M, Chen XQ, Huang HJ, Chen JH, Yang K, Chen SQ, Chen HQ, Kan HD,Sun QH. Effects of Prenatal PM10 Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study. Environ Health Perspect. 2017;125:057001.

15.Gao J, Xu X, Ying Z, Jiang L, Zhong M, Wang A, Chen LC, Lu B,Sun Q. Post-Effect of Air Quality Improvement on Biomarkers for Systemic Inflammation and Microparticles in Asthma Patients After the 2008 Beijing Olympic Games: a Pilot Study. Inflammation. 2017;40:1214-1224.

16.Liu C, Xu X, Bai Y, Zhong J, Wang A, Sun L, Kong L, Ying Z,Sun Q, Rajagopalan S. Particulate Air pollution mediated effects on insulin resistance in mice are independent of CCR2. Part Fibre Toxicol. 2017;14:6.

17.Qiu Y, Zheng Z, Kim H, Yang Z, Zhang G, Shi X, Sun F, Peng C, Ding Y, Wang A, Chen LC, Rajagopalan S,Sun Q, Zhang K. Inhalation Exposure to PM2.5 Counteracts Hepatic Steatosis in Mice Fed High-fat Diet by Stimulating Hepatic Autophagy. Sci Rep. 2017;7:16286.

18.Akinbobola OM, Crawford M,Sun Q. Secondhand smoke: A comparison of exposure to bar employees in a state with smoking bans and a state without smoking bans. Environ Dis 2016;1:65-76

19.Wang S, Sun X, Jiang L, Liu X, Chen M, Yao X,Sun Q, Yang G. 6-Gingerol induces autophagy to protect HUVECs survival from apoptosis. Chem Biol Interact. 2016;256:249-56

20.Zhao J, Liu C; Bai Y; Wang T; Kan H,Sun Q. IKK Inhibition prevents PM2.5-exacerbated cardiac injury in the mice with Type II Diabetes. Journal of Environmental Sciences. 2015;31:98-103

21.Bai Y, Wang D, Jiang L, Liu X, Yang G, Geng C, Zhong L,Sun Q*, Chen M*. The Role of Oxidative Stress in Citreoviridin-Induced DNA Damage in Human Liver-Derived HepG2 Cells. Environ Toxicol 30: 530–537, 2015

22.Bai Y, Shang Y, Liu Z, Lu B andSun Q. Pre-exposure to Fine Particulate Matters may Induce Endotoxin Tolerance in a Mouse Model. Austin J Environ Toxicol. 2015;1(2):1006

23.Ying Z, Xie X, Bai Y, Chen M, Wang X, Zhang X, Morishita M,Sun Q, Rajagopalan S. Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats. Part Fibre Toxicol. 2015;12(1):15

24.Zheng Z, Zhang X, Wang J, Dandeka A, Kim H, Qiu Y, Xu X, Cui Y, Wang A, Chen LC, Rajagopalan S,Sun Q, Zhang K. Exposure to Fine Airborne Particulate Matters Induces Hepatic Fibrosis in Murine Models. J Hepatol. 2015; 63:1397-404.

25.Wang T, Liu C, Wang A,Sun Q. Intermittent cold exposure improves glucose homeostasis associated with brown and white adipose tissues in mice. Life Sci. 2015;139: 153–159

26.Liu C, He X, Hong X, Kang F, Chen S, Wang Q, Chen X, Hu D,Sun Q. Suppression of Placental Metallothionein 1 and Zinc Transporter 1 mRNA Expressions Contributes to Fetal Heart Malformations Caused by Maternal Zinc Deficiency. Cardiovasc Toxicol 2014;14:329–338

27.Rao X, Zhong J, Maiseyeu A, Gopalakrishnan B, Villamena FA, Chen LC, Harkema JR,Sun Q*, and Rajagopalan S*. CD36-dependent 7-ketocholesterol Accumulation in Macrophages Mediates Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure. Circ Res. 2014;115:770-780

28.Liang Y, Fang L, Pan H, Zhang K, Kan H, Brook JR andSun Q. PM2.5 in Beijing - temporal pattern and its association with influenza. Environ Health. 2014;13:102

29.Zheng Z, Xu X, Zhang X, Wang A, Zhang C, Hüttemann M, Grossman LI, Chen LC, Rajagopalan S,Sun Q, and Zhang K. Exposure to Ambient Particulate Matter Induces a NASH-like Phenotype and Impairs Hepatic Glucose Metabolism in an Animal Model. J Hepatol. 2013;58:148-154

30.Mendez R, Zheng Z, Fan Z, Rajagopalan S,Sun Q*, and Zhang K*. Exposure to Fine Airborne Particulate Matter Induces Macrophage Infiltration, Unfolded Protein Response, and Lipid Deposition in White Adipose Tissue. Am J Transl Res 2013;5:224-234

31.Ying Z, Xu X, Chen M, Liu D, Zhong M, Chen LC,Sun Q, Rajagopalan S. A Synergic Vascular Effect of Airborne Particle Matter and Nickel in a Mouse Model. Toxicol Sci Toxicol Sci. 2013;135:72-80

32.Xu X, Jiang SY, Wang TY, Bai Y, Zhong M, Wang A, Lippmann M, Chen LC, Rajagopalan S,Sun Q. Inflammatory Response to Fine Particulate Air Pollution Exposure: Neutrophil versus Monocyte. PLoS ONE 2013;8: e71414

33.Sun L, Liu C , Xu X, Ying Y, Maiseyeu A, Wang A, Allen K, Lewandowski RP, Bramble LA, Morishita M, Wagner JG, Dvonch JT, Sun Z, Yan X, Brook RD, Rajagopalan S, Harkema JR,Sun Q*, Fan Z*. Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet. Part Fibre Toxicol; 2013, 10:43

34.Rao X, Zhong J, Xu X, Jordan B, Maurya S, Braunstein Z, Wang T, Huang W, Aggarwal S, Periasamy M, Rajagopalan S, Mehta K, andSun Q. Exercise protects against diet-induced insulin resistance through downregulation of protein kinase Cβ in mice. PLoS ONE 2013;8: e81364

35.Zheng Z, Zhang C, Yan J, Ruan Y, Zhao X, San X, Mao Y,Sun Q*, Zhang K*, and Fan Z*. Diabetes Mellitus is associated with Hepatocellular Carcinoma: a Retrospective Case-control Study in Hepatitis Endemic Area. PLoS ONE 2013;8: e84776

36.Xu X, Deng F, Guo X, Lv P, Zhong M, Liu C, Wang A, Tzan K, Jiang SY, Lippmann M, Rajagopalan S, Qu Q, Chen LC,Sun Q. Association of systemic inflammation with marked changes in particulate air pollution in Beijing in 2008. Toxicol Lett. 2012;212:147-156

37.Xu X, Liu C, Xu Z, Tzan K, Wang A, Rajagopalan S,Sun Q. Altered adipocyte progenitor population and adipose-related gene profile in adipose tissue by long-term high-fat diet in mice. Life Sci. 2012;90:1001-9

38.Xu X, Rao X, Wang TY, Jiang SY, Ying Z, Liu C, Wang A, Zhong M, Deiuliis JA, Maiseyeu A, Rajagopalan S, Lippmann M, Chen LC, andSun Q. Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model. Particle and Fibre Toxicology; 2012; 9:40