刘翠清,教授,中西医结合基础博士生导师,浙江省自然科学基金获得者(2016),浙江省第八届青年教师教学技能比赛一等奖获得者(2014年),浙江省毒理学会科技奖获得者(2018年),浙江省高校中青年学科带头人(2017)、浙江省首批高校创新领军人才(2020)。现任美高梅mgm1888院长,浙江省科技厅国际合作基地(大气污染与健康国际科技合作基地)主任,美高梅MGM官网中美联合环境与肺系疾病研究中心副主任(常务)。2000年至2003年攻读河北医科大学生理学硕士学位,2005年至2008年攻读复旦大学生理学博士学位(香港中文大学联合培养)。自2003年硕士毕业,就职杭州师范大学任教,2006年至2007年赴香港中文大学做研究助理,2010年至2012年赴美国俄亥俄州立大学做博士后,2015年入职美高梅MGM官网教授,2017年担任美高梅MGM官网基础医学院、美高梅mgm1888副院长。兼任中华中医药学会健康管理分会副主委、中国毒理学会理事、中国环境诱变剂学会致突变委员会常务委员、中国毒理学会表观遗传毒理专委会常务委员、浙江省环境与生态专委会副主委等学术兼职。主要从事环境因素对代谢性心血管疾病的影响及防治的研究。现后获科技部重点研发项目、国家重大研究计划培育项目、国家自然科学基金面上项目、青年项目、浙江省杰出青年基金项目等资助。参编著作三部,在Environ Health Perspect、Particle & Fibre Toxicology、Toxicol Sci、Biochemical Pharmacology等杂志已公开发表SCI收录文章近60篇,部分工作被Environ Health Perspect作为highlight配以专评。
研究方向:
1.环境因素毒性作用;
2.环境污染性疾病的中医药防治
联系方式:
地址:杭州市滨江区滨文路548号
邮箱:liucuiqing@zcmu.edu.cn
主要承担项目:
1. 国家重点研发计划项目(2019YFE0114500),全生命周期 PM2.5 暴露的代谢毒性及干预研究,2020/12-2023/11,主持
2. 国家自然科学基金面上项目,Adrb3甲基化介导糖原代谢紊乱在PM2.5暴露抑制白色脂肪棕色化中的作用研究,2023/01-2027/12,主持
3. 国家自然科学基金面上项目(81973001),基于肺-血-下丘脑轴研究生物钟基因BMAL1调控PM2.5诱发肝脏脂质沉积的作用机制,2020/01-2023/12,主持
4. 国家自然科学基金重大研究计划培育项目(91643103),Exosome/TLR4通路在细颗粒物诱发血压升高中的作用机制,2017/01-2019/12,主持
5. 浙江省自然科学基金杰出青年项目(LR17H260001),Toll样受体3参与调控PM2.5诱发肝脏胰岛素抵抗和脂质代谢紊乱的机制研究,2017/01-12/2020,主持
6. 国家自然科学基金青年项目(81402646),Toll样受体-3在PM2.5诱导胰岛素抵抗中作用及调控机制研究,2015/01-2017/12,主持
7. 浙江省自然科学基金青年项目(LQ13H070002),肺表面活性蛋白D参与调控PM2.5颗粒诱导血管系统胰岛素抵抗的机制研究,2013/01-2015/12,主持
代表性论文:
(1) Zhang G, Wang Y, Li R, Peng J, Zhang J, Hu R, Zhang L, Wu Y, Sun Q, Liu C*. Sex difference in effects of intermittent heat exposure on hepatic lipid and glucose metabolisms. Sci Total Environ. 2022 Sep 13;854:158704. (通讯作者)
(2) Wang Q, Wu Y, Zhang W, Shen T, Li H, Wu J, Zhang L, Qin L, Chen R, Gu W, Sun Q, Liu C*, Li R*. Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice. Chemosphere. 2022 Dec;308(Pt 3):136591. (并列通讯作者)
(3) Chen R, Zhang J, Pang Y, Liu Q, Peng J, Lin X, Cao L, Gu W, Zhang L, Li R, Sun Q, Zhang R, Liu C*. Qianjinweijing Decoction Protects Against Fine Particulate Matter Exposure-mediated Lung Function Disorder. Front Pharmacol. 2022 Jun 24;13:873055. (通讯作者)
(4) Li R, Peng J, Zhang W, Wu Y, Hu R, Chen R, Gu W, Zhang L, Qin L, Zhong M, Chen LC, Sun Q, Liu C*. Ambient fine particulate matter exposure disrupts placental autophagy and fetal development in gestational mice. Ecotoxicol Environ Saf. 2022 May 24;239:113680.(通讯作者)
(5) Zhang J, Chen R, Zhang G, Wang Y, Peng J, Hu R, Li R, Gu W, Zhang L, Sun Q, Liu C*. PM2.5 increases mouse blood pressure by activating toll-like receptor 3. Ecotoxicol Environ Saf. 2022 Mar 2;234:113368. (通讯作者)
(6) Hu R, Zhang W, Li R, Qin L, Chen R, Zhang L, Gu W, Sun Q, Liu C*. Ambient fine particulate matter exposure disrupts circadian rhythm and oscillation of the HPA axis in a mouse model. Ecotoxicol Environ Saf. 2021 Oct 1;222:112524. (通讯作者)
(7) Zhang G, Li R, Li W, Yang S, Sun Q, Yin H, Wang C, Hou L, Wang H, Yu L, Chen R, Shi L, Zhang K, Liew C, Qiang G, Sun Q, Liu C*. Toll-like receptor 3 ablation prevente d high-fat diet-induce d obesity and metabolic disorder. Journal of Nutritional Biochemistry. 2021 Apr 95:108761(通讯作者)
(8) Yang S, Chen R, Zhang L, Sun Q, Li R, Gu W, Zhong M, Liu Y, Chen LC, Sun Q, Liu C*. Lipid metabolic adaption to long-term ambient PM2.5 exposure in mice. Environ Pollut. 2020;269:116193.(通讯作者)
(9) Li R, Wang Y, Qiu X, Xu F, Chen R, Gu W, Zhang L, Yang S, Cai, Z, Liu C*. Difference on oxidative stress in lung epithelial cells and macrophages induced by ambient fine particulate matter (PM2.5). Air Quality, Atmosphere and Health.2020;13:789-796.(通讯作者)
(10) Wang Y, Li R, Chen R, Gu W, Zhang L, Gu J, Wang Z, Liu Y, Sun Q, Zhang K, Liu C*. Ambient fine particulate matter exposure perturbed circadian rhythm and oscillations of lipid metabolism in adipose tissues. Chemosphere. 2020. 251:126392.(通讯作者)
(11) Li R, Wang Y, Hou B, Lam S, Zhang W, Chen R, Shui G, Sun Q, Qiang G, Liu C*. Lipidomics insight into chronic exposure to ambient air pollution in mice. Environmental Pollution. 2020. 262:114668.(通讯作者)
(12) Li R, Wang Y, Chen R, Gu W, Zhang L, Gu J, Wang Z, Liu Y, Sun Q, Zhang K, Liu C*. Ambient fine particulate matter disrupts hepatic circadian oscillation and lipid metabolism in a mouse model. Environmental Pollution. 2020. 262:114179.(通讯作者)
(13) Li R, Sun Q, Lam S, Chen R, Zhu J, Gu W, Zhang L, Tian H, Zhang K, Chen L, Sun Q, Shui G*, Liu C*. Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice. Part Fibre Toxicol. 2020.17. 17(1):14. doi: 10.1186/s12989-020-00343-5.(通讯作者)
(14) Sun Q, Zhang G, Chen R, Li R, Wang H, Jiang A, Li Z, Kong L, Fonken LK, Rajagopalan S, Sun Q*, Liu C*. Central IKK2 inhibition ameliorates air pollution mediated hepatic glucose and lipid metabolism dysfunction in mice with type II diabetes. Toxicol Sci. 2018; 240-249.(通讯作者)
(15) Liu C*, Xu X, Bai Y, Zhong J, Wang A, Sun L, Kong L, Ying Z, Sun Q, Rajagopalan S*. Particulate Air Pollution Mediated Effects on Insulin Resistance in Mice are Independent of CCR2. Part Fibre Toxicol. 2017;14(1):6. doi: 10.1186/s12989-017-0187-3.(第一兼并列通讯作者)
(16) Liu C*, Huang Y*. Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action. Front. Pharmacol. 2016.7:469. doi:10.3389/fphar.2016.00469.(第一兼并列通讯作者)
(17) Zhang G, Sun Q, Liu C*. Influencing Factors of Thermogenic Adipose Tissue Activity.Front Physiol. 2016 Feb 5;7:29. doi: 10.3389/fphys. 2016.00029(通讯作者)
(18) Liu C, Yavar Z, Sun Q*.Cardiovascular Response to Thermoregulatory Challenges. Am J Physiol Heart Circ Physiol.2015. 2015 Dec 1;309(11):H1793-812.(第一作者)
(19) Liu C, Fonken L, Xu X, Wang A, Bai Y, Wang TY, Maurya S, Periasamy M, Morishita M, Brook R, Harkema J, Ying Z, Sun Q, Randy N, Rajagopalan S. Central IKKβ Inhibition Prevents Air Pollution Mediated Peripheral Inflammation and Exaggeration of Type II Diabetes. Particle & Fibre Toxicology. 2014 Oct 30;11(1):53. doi: 10.1186/s12989-014-0053-5.(第一作者)
(20) Liu C, Bai Y, Xu X, Sun L, Wang A, Wang TY, Maurya S, Periasamy M, Morishita M, Harkema J, Ying Z, Sun Q, Rajagopalan S. Exaggerated Effect of Particulate Matter in Genetic Type II Diabetes Mellitus. Particle & Fibre Toxicology. 2014 May 30;11:27. doi: 10.1186/1743-8977-11-27.(第一作者)
(21) Liu C, Xu X, Bai Y, Wang TY, Rao X, Wang A, Sun L, Ying Z, Gushchina L, Maiseyeu A, Morishita M, Sun Q, Harkema JR, Rajagopalan S. Air Pollution-Mediated Susceptibility to Inflammation and Insulin Resistance: Influence of CCR2 Pathways in Mice. Environ Health Perspect. 2014 Jan; 122(1):17-26. (第一作者)