陈栩燊，理学博士，副研究员，硕士研究生导师。
本科毕业于武汉大学生物科学专业，硕士和博士毕业于中山大学遗传学专业，在美国纽约州立大学布法罗分校美高梅mgm1888完成博士后训练。作为核心研究人员，参与多项美国国家环境健康科学研究所（NIEHS）、美国国家癌症研究所（NCI）、国家自然科学基金等多项公共卫生领域及基础和转化医学项目。研究方向主要从多组学角度（转录组学、表观基因组学、蛋白组学、代谢组学、微生物组学），探讨环境化学污染物（如，砷、镉）暴露对细胞和机体的影响和机制，以及相关治疗预防药物的研发。在Ecotoxicology and Environmental Safety、Nucleic Acids Research、Environment International、Science of the Total Environment、Archives of Toxicology等国际重要学术SCI期刊发表学术论文十多篇。
研究方向：
环境化学污染物致病机制和防治
联系方式：
地址：杭州市滨江区滨文路548号
邮箱：xushenchen@zcmu.edu.cn
主要承担项目：
1. 国家自然科学基金面上项目，8237117，孕期镉暴露导致的脑神经突触功能异常的分子机制及其在儿童自闭症发生发展中关系研究，2024.01.01-2027.12.31，参与，在研；
2. 美高梅MGM官网校级科研项目（人才专项），2022RCZXZK03，肠道微生物在砷暴露致睾丸及附睾生殖毒性损伤中的作用及机制探讨，2023.01-2025.12，主持，在研；
3. 企业横向项目，躁狂性抑郁症中药治疗干预研究，2022.12-2025.11，主持，在研；
4. 美高梅MGM官网青年人才蓄水池发展基金，饮水型砷暴露致膀胱和生殖系统损伤的机制研究，2022.10-2024.09，主持，在研。
代表性论文：
1. Chen X, Cheng Y, Tian X, Li J, Ying X, Zhao Q, Wang M, Liu Y, Qiu Y, Yan X, Ren X. Urinary microbiota and metabolic signatures associated with inorganic arsenic-induced early bladder lesions. Ecotoxicology and Environmental Safety, 2023, 259: 115010.
2. Ge Y, Chen X, Nan N, Bard J, Wu F, Yergeau D, Liu T, Wang J, Mu X. Key transcription factors influence the epigenetic landscape to regulate retinal cell differentiation. Nucleic Acids Research, 2023, 51: 2151-2176.
3. Tian X, Yan X, Chen X, Liu P, Sun Z, Niu R. Identifying Serum Metabolites and Gut Bacterial Species Associated with Nephrotoxicity Caused by Arsenic and Fluoride Exposure. Biological Trace Element Research, 2023: 1-12.
4. Yan X*, Chen X*, Tian X, Qiu Y, Wang J, Yu G, Dong N, Feng J, Xie J, Nalesnik M, Xiao B, Song G, Quinones S, Ren X. Co-exposure to inorganic arsenic and fluoride prominently disrupts gut microbiota equilibrium and induces adverse cardiovascular effects in offspring rats. Science of the Total Environment, 2021, 767: 144924. （共同一作）
5. Qiu Y*, Chen X*, Yan X, Wang J, Yu G, Ma W, Xiao B, Quinones S, Tian X, Ren X: Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride. Environment International, 2020, 140: 105763. （共同一作）
6. Tian X, Xie J, Chen X, Dong N, Feng J, Gao Y, Tian F, Zhang W, Qiu Y, Niu R, Ren X, Yan X. Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring. Archives of Toxicology, 2019: 1-12.
7. Liu Y*, Chen X*, Gong Z*, Zhang H, Fei F, Tang X, Wang J, Xu P, Zarbl H, Ren X. Fry is required for mammary gland development during pregnant periods and affects the morphology and growth of breast cancer cells. Frontiers in Oncology, 2019, 9: 1279. （共同一作）
8. Ge Y, Zheng N, Chen X, Zhu J, Sun W, Olson J, Aga D, Hu W, Tang X, Ren X. GMDTC Chelating Agent Attenuates Cisplatin-Induced Systemic Toxicity without Affecting Antitumor Efficacy. Chemical Research in Toxicology, 2019, 32: 1572-1582.
9. Guo X*, Chen X*, Wang J*, Liu Z, Gaile D, Wu H, Yu G, Mao G, Yang Z, Di Z, Guo X, Cao L, Chang P, Kang B, Chen J, Gao W, Ren X. Multi-generational Impacts of Arsenic Exposure on Genome-wide DNA Methylation and the Implications for Arsenic-induces Skin Lesions. Environment International, 2018, 119: 250-263. （共同一作）
10. Zhu J, Wang J, Chen X, Tsompana M, Gaile D, Buck M, Ren X. A time-series analysis of altered histone H3 acetylation and gene expression during the course of MMAIII-induced malignant transformation of urinary bladder cells. Carcinogenesis, 2017, 38: 378-390.
11. Chen X, Guo X, He P, Nie J, Yan X, Zhu J, Zhang L, Mao G, Wu H, Liu Z, Aga D, Xu P, Smith M, Ren X. Interactive influence of N6AMT1 and As3MT genetic variations on arsenic metabolism in the population of Inner Mongolia, China. Toxicological Sciences, 2016, 155: 124-134.
12. Kong Q, Chen XS, Tian T, Xia XY, Xu P. MicroRNA-194 suppresses prostate cancer migration and invasion by downregulating human nuclear distribution protein. Oncology Reports, 2017, 37: 803-812.
13. Zhang H, Ge Y, He P, Chen X, Carina A, Qiu Y, Aga DS, Ren X. Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation. Toxicological Sciences, 2015, 146: 354-362.
14. Zhang YP, Tang YS, Chen XS, Xu P. Regulation of cell differentiation by hNUDC via a Mpl-dependent mechanism in NIH 3T3 cells. Experimental Cell Research, 2007, 313: 3210-3221.
