李冉，博士，副教授，硕士生导师，卫生毒理教研室主任。美高梅MGM官网“远志优青”，2021年获浙江省毒理学科技奖，2022年入选“浙江省高校领军人才培养计划”青年拔尖人才；兼任中国毒理学会呼吸毒理专委会青年委员、中国毒理学会毒理学教育专委会青年委员、中国环境诱变剂学会致突变专委会委员、中国环境诱变剂学会环境与发育源性疾病专委会委员和浙江省预防医学会卫生毒理专委会委员。主要从事环境与健康方向研究，重点关注空气污染物和新型环境污染物的发育毒性及代谢毒性；先后主持国家自然科学基金2项和浙江省自然科学基金项目等多项课题；在Part Fibre Toxicol和Environ Pollut等期刊累积发表论文30余篇。
研究方向：
1.环境与健康
联系方式：
地址：浙江省杭州市滨江区滨文路548号
邮箱：ranli@zcmu.edu.cn
主要科研项目：
1. 国家自然科学基金面上项目，颗粒蛋白前体（PGRN）在PM2.5诱发胎儿宫内生长受限中的作用及机制（No. 82173480），2021/01-2025/12，主持。
2. 国家自然科学基金青年项目，活性氧介导的胎盘内质网应激在1-硝基芘诱发胎儿生长受限中的作用（No. 31601192），2017/01-2019/12，主持。
3. 浙江省自然科学基金探索，氧化应激负调控胎盘AKT/eNOS通路在PM2.5诱发宫内生长受限中的作用及机制（No. LY20H260004），2020/01-2022/12，主持。
4. 环境模拟与污染控制国家重点联合实验室开放课题，北京地区PM2.5诱发肺部细胞氧化应激的机制研究（No. 16K04ESPCP），2016/06-2017/06，主持。
5. 国家重点研发计划项目，全生命周期PM2.5暴露的代谢毒性及干预研究（No. 2019YFE0114500），2020/12-2023/11，参与。
6. 国家自然科学基金面上基金，基于肺-血-下丘脑轴研究生物钟基因BMAL1调控PM2.5诱发肝脏脂质沉积的作用机制（No. 81973001），2020/01-2023/12，参与。
代表性论文：
1. Yirun Wang; Zhuan Chen; Jie Li; Teng Wan; Renjie Hu; Lu Zhang; Li Qin; Lu Zang; Weijia Gu; Rucheng Chen; Cuiqing Liu; Ran Li. Gestational exposure to PM2.5 disrupts fetal development by suppressing placental trophoblast syncytialization via progranulin/mTOR signaling, Science of the Total Environment, 2024, 921:171101.
2. Yunlu Wu; Yirun Wang; Wenhui Zhang; Jing Peng; Li Qin; Lu Zhang; Rucheng Chen; Weijia Gu; Qinghua Sun; Cuiqing Liu; Ran Li. Gestational exposure to ambient fine particulate matter disrupts maternal hepatic lipid metabolism, Chemosphere, 2023, 344:140369.
3. Ting Shen; Wenjing Zhang; Yirun Wang; Haizhu Li; Jingwei Wu; Qian Wang; Yunlu Wu; Li Qin; Lu Zhang; Cuiqing Liu; Ran Li. Molecules, 2022, 28 (20).
4. Qian Wang; Yunlu Wu; Wenjing Zhang; Ting Shen; Haizhu Li; Jingwei Wu; Lu Zhang; Li Qin; Rucheng Chen; Weijing Gu; Qinghua Sun; Cuiqing Liu; Ran Li. Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice, Chemosphere, 2022, 308: 136591.
5. Ran Li; Jing Peng; Wenhui Zhang; Yunlu Wu; Renjie Hu; Rucheng Chen; Weijia Gu; Lu Zhang; Li Qin; Mianhua Zhong; Lung-Chi Chen; Qinghua Sun; Cuiqing Liu. Ambient fine particulate matter exposure disrypts placental autophagy and fetal development in gestational mice, Ecotoxicology and Environmental Safety, 2022, 239: 113680.
6. Ran Li; Qing Sun; Sin Man Lam; Rucheng Chen; Junyao Zhu; Weijia Gu; Lu Zhang; He Tian; Kezhong Zhang; Lung-Chi Chen; Qinghua Sun; Guanghou Shui; Cuiqing Liu. Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice, Particle and Fibre Toxicology, 2020, 17(1): 14.
7. Ran Li; Yixuan Wang; Rucheng Chen; Weijia Gu; Lu Zhang; Jinge Gu; Ziyao Wang; Ying Liu; Qinghua Sun; Kezhong Zhang; Cuiqing Liu. Ambient fine particulate matter disrupts hepatic circadian oscillation and lipid metabolism in a mouse model, Environmental Pollution, 2020, 262: 114179.
8. Ran Li; Yixuan Wang; Biyu Hou; Sin Man Lam; Wenhui Zhang; Rucheng Chen; Guanghou Shui; Qinghua Sun; Guifeng Qiang; Cuiqing Liu. Lipidomics insight into chronic exposure to ambient air pollution in mice, Environmental Pollution, 2020, 262: 114668.
9. Ran Li; Xilu Wang; Bo Wang; Jian Li; Yaping Song; Biao Luo; Yuanhua Chen; Cheng Zhang; Hua Wang; Dexiang Xu. Gestational 1-nitropyrene exposure causes gender-specific impairments on postnatal growth and neurobehavioral development in mice, Ecotoxicology and Environmental Safety, 2019, 180: 123-129.
10. Ran Li; Xilu Wang; Bo Wang; Jian Li; Yaping Song; Biao Luo; Yuanhua Chen; Cheng Zhang; Hua Wang; Dexiang Xu. Gestational 1-nitropyrene exposure causes fetal growth restriction through disturbing placental vascularity and proliferation, Chemosphere, 2018, 213: 252-258.
